April often takes a support role in video games, and in the Konami series of TMNT games based on the 2003 TV series, April resembles her cartoon counterpart. She is one of the few friends Turtles considered to be part of the family. A smart engineer and owner of an antique shop. She has feels toward Casey but both seem to have a hard time trying to express their own feelings. Like in the 2003 show, she is no longer a mere damsel-in-distress but often shows up in various cutscenes to give advice and advance the plot of the game. Her role is ordinarily identical to that seen within the series. However, there are a couple of key differences.
In TMNT: Mutant Melee, April is once again a playable character and participates in multi-player battles, using mostly kick attacks. Her super move is a rotating spin-kick attack. Two unlockable versions of April include her wearing outfits fit for winter and for summer; these Aprils are essentially alternate costumes given their own select screen slots.