As can be expected, the Bigfoot in the games based on the 2007 movie is modeled after the Bigfoot in that film.
Bigfoot functions as a boss in TMNT (2007 game) and is the only boss in TMNT: Ninja Adventures. In TMNT (Game Boy Advance), he attacks the Foot Clan at the end of level 2 with barrels, but the player does not fight it; instead, they battle Karai.