When playing "Turtle Hunt" Mikey and Donnie were attacked by Bigfoot, who was scared and hurt, Donnie takes her to the farmhouse and takes care of her. Bigfoot falls for Donnie who is not interested, later Leonardo hurts her feelings and she runs to the woods. Mikey and Donnie fight The Finger to protect Bigfoot, but as The Finger discovers Bigfoot is a female he gave up on his hunt as he can't hurt a lady. At the end Bigfoot and The Finger fall in love and disappear in the woods.
In Dinosaur Seen in Sewers! a newspaper has "Bigfoot and I are expecting" in a New York news tabloid, implying that The Finger and Bigfoot will have a baby.
- Bigfoot is the second cryptid to be voiced by Diedrich Bader, the first being Fiskerton Phantom, a Gorilla-Cat in The Secret Saturdays.
- According to Donatello, Bigfoot is said to be a paranthropus robustus, a hominid long thought to be extinct, hence the aforementioned "sagittal crest".
- Unlike most depictions of Bigfoot, this incarnation is female.