Creepweed is a bug-like plant creature with multiple tentacles with spikes. Creepweed is brownish greenish and has four big green glowing eyes and a glowing mouth.
As it terrorized New York City and put people to sleep in pods, Michelangelo, Leonardo, and Raphael went to stop it. Though Leo and Raph were undone by Creepweed's sleep stench, Michelangelo managed to knock down Creepweed but the creature then grabbed Mikey and he was about to meet his doom when a freshly recovered Donatello appeared with a Retro-Mutagen-based weed killer and defeated the monster. He then stored what remained of Creepweed in a metal box so that it can't get out or Mikey can't accidentally break it.
- Creepweed was one of only three known mutant fusions in the 2012 series. The others being Chimera and Mega Shredder.
- Creepweed is similar and somewhat resembles the kaiju Biollante from Toho's 1989 film Godzilla vs. Biollante.