Karai's role in video games is very much the same as it was in Teenage Mutant Ninja Turtles (2003 TV series), as a sometime enemy, sometime ally. In Teenage Mutant Ninja Turtles 2: Battle Nexus, she is a recurring boss character, and eventually becomes an unlockable player.
In Teenage Mutant Ninja Turtles Smash-Up, she is an unlockable player for all modes. Her model is based on 2007 film version, like all of the other characters that appeared in both the 2003 series and 2007 film. Her portion of the story involves her wanting to overthrow her father and take over the Foot Clan. Her alternate costume in this game is similar to those of the Amazonian Blade Bots.