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The Mona Lisa is an artwork by Leonardo da Vinci, depicting a smiling woman. It currently is located in the Louvre Museum in Paris, France.

In the 1987 TMNT cartoon episode Tower of Power, the Turtles view the artwork when visiting the Louvre in Paris.

In the episode Rust Never Sleeps of the same show, the Turtles stop a guy from destroying the artwork by throwing a bottle with paint on it.