In most of the original TMNT video games, the Technodrome is the final level of the game and that the Turtles must fight their way through the various section of the Technodrome to get to the final boss, alternatively either Shredder or Krang depending on the game.
In the 1989 game, the Technodrome itself works a boss character for the next to last level of the game. In order to move to the last level, which is set inside of the Technodrome, the Turtles must first defeat the Technodrome, which is portrayed as a huge screen filling boss. Defeating the Technodrome requires the player to destroy the base's outer gun turrets and the giant eye periscope at the top of the Technodrome.
The interior of the Technodrome changes from game to game: in the first Turtles NES game, the inside of the Technodrome was yellow and blue and looked like a war zone. It also included some of the bosses of the earlier levels, who did not belong in the Technodrome. However, in later games the interior of the Technodrome began to match the Technodrome depicted in the cartoon series. It started including the mouser factory, security drones, and more fitting inhabitants. The first part of the Teenage Mutant Ninja Turtles: The Hyperstone Heist Technodrome level is actually based on the Starbase level from Teenage Mutant Ninja Turtles: Turtles in Time.
The Technodrome also appears in the background of the Underground stage in the new 2009 fighting game, Teenage Mutant Ninja Turtles Smash-Up, firing off lasers that causes partial cave-ins on the battlefield.
The 1987 Technodrome appears in the background of level 3 in Donnie Saves a Princess.